Description
14-3-3 eta (also known as tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein, eta polypeptide) plays a key role in tissue differentiation in neural development and in early mesenchyme. The 14-3-3 eta protein belongs to family of acidic proteins present exclusively in the brain and is believed to have a function in monoamine biosynthesis. 14-3-3 eta protein regulates human tyrosine hydroxylase type 1 (hTH1) stability by acting on the N-terminus. 14-3-3 eta can bind to parkin, which encodes an E3 ubiquitin-protein ligase, in the linker region and negatively regulate its ubiquitin ligase activity